Lexus IS 350 MPG by Year & Engine (EPA)
EPA fuel-economy ratings for every rated Lexus IS 350 model year from 2006 to 2026 — each engine and transmission with its official city, highway and combined figures. Over these years the IS 350 has been offered with 3.5L 6-cyl engines; the most efficient version is the 2025 (up to 23 MPG combined). Every rated gas version calls for premium gasoline. Data: U.S. Department of Energy & EPA, fueleconomy.gov; prices are live medians from VehiSales listings.
Lexus IS 350 fuel economy by year
| Year | Combined | Engines | Median used price | For sale |
|---|---|---|---|---|
| 2026 | 22 MPG | 3.5L 6-cyl | $52,750 | 48 listings |
| 2025 | 22–23 MPG | 3.5L 6-cyl | $50,624 | 20 listings |
| 2024 | 22–23 MPG | 3.5L 6-cyl | $43,998 | 44 listings |
| 2023 | 22–23 MPG | 3.5L 6-cyl | $41,986 | 43 listings |
| 2022 | 22–23 MPG | 3.5L 6-cyl | $39,992 | 86 listings |
| 2021 | 22–23 MPG | 3.5L 6-cyl | $37,980 | 72 listings |
| 2020 | 21–23 MPG | 3.5L 6-cyl | $30,598 | 6 listings |
| 2019 | 21–23 MPG | 3.5L 6-cyl | — | — |
| 2018 | 22–23 MPG | 3.5L 6-cyl | $31,988 | 5 listings |
| 2017 | 21–22 MPG | 3.5L 6-cyl | $27,293 | 12 listings |
| 2016 | 21–22 MPG | 3.5L 6-cyl | $14,950 | 10 listings |
| 2015 | 21–22 MPG | 3.5L 6-cyl | $22,445 | 8 listings |
| 2014 | 21–22 MPG | 3.5L 6-cyl | — | — |
| 2013 | 22 MPG | 3.5L 6-cyl | — | — |
| 2012 | 21–22 MPG | 3.5L 6-cyl | — | — |
| 2011 | 20–22 MPG | 3.5L 6-cyl | — | — |
| 2010 | 20 MPG | 3.5L 6-cyl | — | — |
| 2009 | 20 MPG | 3.5L 6-cyl | — | — |
| 2008 | 20 MPG | 3.5L 6-cyl | — | — |
| 2007 | 21 MPG | 3.5L 6-cyl | — | — |
| 2006 | 21 MPG | 3.5L 6-cyl | — | — |
2026 Lexus IS 350: engines & MPG
The 2026 IS 350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy of 22 MPG. Used 2026 models currently list for a median of $52,750 on VehiSales (48 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S8) | Premium | 19 | 27 | 22 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 22 MPG |
2025 Lexus IS 350: engines & MPG
The 2025 IS 350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 22 to 23 MPG. Used 2025 models currently list for a median of $50,624 on VehiSales (20 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S8) | Premium | 20 | 28 | 23 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 22 MPG |
2024 Lexus IS 350: engines & MPG
The 2024 IS 350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 22 to 23 MPG. Used 2024 models currently list for a median of $43,998 on VehiSales (44 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S8) | Premium | 20 | 28 | 23 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 22 MPG |
2023 Lexus IS 350: engines & MPG
The 2023 IS 350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 22 to 23 MPG. Used 2023 models currently list for a median of $41,986 on VehiSales (43 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S8) | Premium | 20 | 28 | 23 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 22 MPG |
2022 Lexus IS 350: engines & MPG
The 2022 IS 350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 22 to 23 MPG. Used 2022 models currently list for a median of $39,992 on VehiSales (86 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S8) | Premium | 20 | 28 | 23 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 22 MPG |
2021 Lexus IS 350: engines & MPG
The 2021 IS 350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 22 to 23 MPG. Used 2021 models currently list for a median of $37,980 on VehiSales (72 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S8) | Premium | 20 | 28 | 23 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 22 MPG |
2020 Lexus IS 350: engines & MPG
The 2020 IS 350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 21 to 23 MPG. Used 2020 models currently list for a median of $30,598 on VehiSales (6 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S8) | Premium | 20 | 28 | 23 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 21 MPG |
2019 Lexus IS 350: engines & MPG
The 2019 IS 350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 21 to 23 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S8) | Premium | 20 | 28 | 23 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 21 MPG |
2018 Lexus IS 350: engines & MPG
The 2018 IS 350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 22 to 23 MPG. Used 2018 models currently list for a median of $31,988 on VehiSales (5 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S8) | Premium | 20 | 28 | 23 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 22 MPG |
2017 Lexus IS 350: engines & MPG
The 2017 IS 350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 21 to 22 MPG. Used 2017 models currently list for a median of $27,293 on VehiSales (12 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S8) | Premium | 19 | 28 | 22 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 21 MPG |
2016 Lexus IS 350: engines & MPG
The 2016 IS 350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 21 to 22 MPG. Used 2016 models currently list for a median of $14,950 on VehiSales (10 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S8) | Premium | 19 | 28 | 22 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 21 MPG |
2015 Lexus IS 350: engines & MPG
The 2015 IS 350 was EPA-rated in 3 versions (3.5L 6-cyl), with combined economy from 21 to 22 MPG. Used 2015 models currently list for a median of $22,445 on VehiSales (8 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 C | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 27 | 22 MPG |
| IS 350 | 3.5L 6-cyl | Automatic (S8) | Premium | 19 | 28 | 22 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 21 MPG |
2014 Lexus IS 350: engines & MPG
The 2014 IS 350 was EPA-rated in 3 versions (3.5L 6-cyl), with combined economy from 21 to 22 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S8) | Premium | 19 | 28 | 22 MPG |
| IS 350 C | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 27 | 22 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 21 MPG |
2013 Lexus IS 350: engines & MPG
The 2013 IS 350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy of 22 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350/IS 350C | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 27 | 22 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 22 MPG |
2012 Lexus IS 350: engines & MPG
The 2012 IS 350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 21 to 22 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350/IS 350C | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 27 | 22 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 18 | 25 | 21 MPG |
2011 Lexus IS 350: engines & MPG
The 2011 IS 350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 20 to 22 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350/IS 350C | 3.5L 6-cyl | Automatic (S6) | Premium | 20 | 27 | 22 MPG |
| IS 350 AWD | 3.5L 6-cyl | Automatic (S6) | Premium | 18 | 25 | 20 MPG |
2010 Lexus IS 350: engines & MPG
The 2010 IS 350 was EPA-rated in 1 version (3.5L 6-cyl), with combined economy of 20 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350/IS 350C | 3.5L 6-cyl | Automatic (S6) | Premium | 18 | 25 | 20 MPG |
2009 Lexus IS 350: engines & MPG
The 2009 IS 350 was EPA-rated in 1 version (3.5L 6-cyl), with combined economy of 20 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S6) | Premium | 18 | 25 | 20 MPG |
2008 Lexus IS 350: engines & MPG
The 2008 IS 350 was EPA-rated in 1 version (3.5L 6-cyl), with combined economy of 20 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S6) | Premium | 18 | 25 | 20 MPG |
2007 Lexus IS 350: engines & MPG
The 2007 IS 350 was EPA-rated in 1 version (3.5L 6-cyl), with combined economy of 21 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 25 | 21 MPG |
2006 Lexus IS 350: engines & MPG
The 2006 IS 350 was EPA-rated in 1 version (3.5L 6-cyl), with combined economy of 21 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| IS 350 | 3.5L 6-cyl | Automatic (S6) | Premium | 19 | 26 | 21 MPG |
Frequently asked questions
What MPG does a Lexus IS 350 get?
Depending on year and engine, EPA combined ratings for the IS 350 range from 20 to 23 MPG. The most efficient rated version is the 2025 model year.
What engines does the 2026 Lexus IS 350 have?
The 2026 IS 350 was EPA-rated with 3.5L 6-cyl engines — see the 2026 table above for each version's exact city/highway figures.
Does the Lexus IS 350 require premium gas?
Yes — every EPA-rated gas IS 350 version specifies premium gasoline.
https://vehisales.com/research/fuel-economy/lexus/is-350.
See also: Lexus IS 350 hub — live listings, prices & reliability · Most fuel-efficient cars by segment · Model price trends. Media inquiries: [email protected].