Lexus RX 450H MPG by Year & Engine (EPA)
EPA fuel-economy ratings for every rated Lexus RX 450H model year from 2010 to 2025 — each engine and transmission with its official city, highway and combined figures. Over these years the RX 450H has been offered with 2.5L 4-cyl, 3.5L 6-cyl engines; the most efficient version is the 2025 (up to 35 MPG combined). Every rated gas version calls for premium gasoline. Data: U.S. Department of Energy & EPA, fueleconomy.gov; prices are live medians from VehiSales listings.
Lexus RX 450H fuel economy by year
| Year | Combined | Engines | Median used price | For sale |
|---|---|---|---|---|
| 2025 | 35 MPG | 2.5L 4-cyl | — | — |
| 2022 | 29–30 MPG | 3.5L 6-cyl | $42,998 | 20 listings |
| 2021 | 29–30 MPG | 3.5L 6-cyl | $42,995 | 14 listings |
| 2020 | 29–30 MPG | 3.5L 6-cyl | $37,995 | 31 listings |
| 2019 | 29–30 MPG | 3.5L 6-cyl | $29,300 | 8 listings |
| 2018 | 29–30 MPG | 3.5L 6-cyl | $30,222 | 12 listings |
| 2017 | 30 MPG | 3.5L 6-cyl | $27,495 | 12 listings |
| 2016 | 30 MPG | 3.5L 6-cyl | $26,999 | 6 listings |
| 2015 | 28–29 MPG | 3.5L 6-cyl | $17,998 | 34 listings |
| 2014 | 28–29 MPG | 3.5L 6-cyl | — | — |
| 2013 | 28–29 MPG | 3.5L 6-cyl | — | — |
| 2012 | 28–29 MPG | 3.5L 6-cyl | — | — |
| 2011 | 28–29 MPG | 3.5L 6-cyl | — | — |
| 2010 | 29–30 MPG | 3.5L 6-cyl | — | — |
2025 Lexus RX 450H: engines & MPG
The 2025 RX 450H was EPA-rated in 1 version (2.5L 4-cyl), with combined economy of 35 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| RX 450h Plus AWD | 2.5L 4-cyl | Automatic (AV-S6) | Premium | 36 | 33 | 35 MPG · 56 MPGe on electricity · 540 mi range |
2022 Lexus RX 450H: engines & MPG
The 2022 RX 450H was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 29 to 30 MPG. Used 2022 models currently list for a median of $42,998 on VehiSales (20 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| RX 450h AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 31 | 28 | 30 MPG |
| RX 450h L AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 29 | 28 | 29 MPG |
2021 Lexus RX 450H: engines & MPG
The 2021 RX 450H was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 29 to 30 MPG. Used 2021 models currently list for a median of $42,995 on VehiSales (14 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| RX 450h AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 31 | 28 | 30 MPG |
| RX 450h L AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 29 | 28 | 29 MPG |
2020 Lexus RX 450H: engines & MPG
The 2020 RX 450H was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 29 to 30 MPG. Used 2020 models currently list for a median of $37,995 on VehiSales (31 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| RX 450h AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 31 | 28 | 30 MPG |
| RX 450h L AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 29 | 28 | 29 MPG |
2019 Lexus RX 450H: engines & MPG
The 2019 RX 450H was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 29 to 30 MPG. Used 2019 models currently list for a median of $29,300 on VehiSales (8 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| RX 450h AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 31 | 28 | 30 MPG |
| RX 450h L AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 29 | 28 | 29 MPG |
2018 Lexus RX 450H: engines & MPG
The 2018 RX 450H was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 29 to 30 MPG. Used 2018 models currently list for a median of $30,222 on VehiSales (12 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| RX 450h AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 31 | 28 | 30 MPG |
| RX 450h L AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 29 | 28 | 29 MPG |
2017 Lexus RX 450H: engines & MPG
The 2017 RX 450H was EPA-rated in 1 version (3.5L 6-cyl), with combined economy of 30 MPG. Used 2017 models currently list for a median of $27,495 on VehiSales (12 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| RX 450h AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 31 | 28 | 30 MPG |
2016 Lexus RX 450H: engines & MPG
The 2016 RX 450H was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy of 30 MPG. Used 2016 models currently list for a median of $26,999 on VehiSales (6 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| RX 450h AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 30 | 28 | 30 MPG |
| RX 450h | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 31 | 30 | 30 MPG |
2015 Lexus RX 450H: engines & MPG
The 2015 RX 450H was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 28 to 29 MPG. Used 2015 models currently list for a median of $17,998 on VehiSales (34 for sale).
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| RX 450h | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 31 | 28 | 29 MPG |
| RX 450h AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 29 | 27 | 28 MPG |
2014 Lexus RX 450H: engines & MPG
The 2014 RX 450H was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 28 to 29 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| RX 450h | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 31 | 28 | 29 MPG |
| RX 450h AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 29 | 27 | 28 MPG |
2013 Lexus RX 450H: engines & MPG
The 2013 RX 450H was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 28 to 29 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| RX 450h | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 31 | 28 | 29 MPG |
| RX 450h AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 29 | 27 | 28 MPG |
2012 Lexus RX 450H: engines & MPG
The 2012 RX 450H was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 28 to 29 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| RX 450h | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 31 | 28 | 29 MPG |
| RX 450h AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 29 | 27 | 28 MPG |
2011 Lexus RX 450H: engines & MPG
The 2011 RX 450H was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 28 to 29 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| RX 450h | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 31 | 28 | 29 MPG |
| RX 450h AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 29 | 27 | 28 MPG |
2010 Lexus RX 450H: engines & MPG
The 2010 RX 450H was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 29 to 30 MPG.
| Version | Engine | Transmission | Fuel | City | Hwy | Combined |
|---|---|---|---|---|---|---|
| RX 450h | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 32 | 28 | 30 MPG |
| RX 450h AWD | 3.5L 6-cyl | Automatic (AV-S6) | Premium | 30 | 28 | 29 MPG |
Frequently asked questions
What MPG does a Lexus RX 450H get?
Depending on year and engine, EPA combined ratings for the RX 450H range from 29 to 35 MPG. The most efficient rated version is the 2025 model year.
What engines does the 2025 Lexus RX 450H have?
The 2025 RX 450H was EPA-rated with 2.5L 4-cyl engines — see the 2025 table above for each version's exact city/highway figures.
Does the Lexus RX 450H require premium gas?
Yes — every EPA-rated gas RX 450H version specifies premium gasoline.
Is there a hybrid or electric RX 450H?
Yes — the ratings above include hybrid versions; look for them in the per-year tables.
https://vehisales.com/research/fuel-economy/lexus/rx-450h.
See also: Lexus RX 450H hub — live listings, prices & reliability · Most fuel-efficient cars by segment · Model price trends. Media inquiries: [email protected].