Mercedes-Benz Ml350 MPG by Year & Engine (EPA)

EPA fuel-economy ratings for every rated Mercedes-Benz Ml350 model year from 2003 to 2015 — each engine and transmission with its official city, highway and combined figures. Over these years the Ml350 has been offered with 3.5L 6-cyl, 3.7L 6-cyl engines; the most efficient version is the 2015 (up to 20 MPG combined). Every rated gas version calls for premium gasoline. Data: U.S. Department of Energy & EPA, fueleconomy.gov; prices are live medians from VehiSales listings.

Mercedes-Benz Ml350 fuel economy by year

YearCombinedEnginesMedian used priceFor sale
2015 19–20 MPG 3.5L 6-cyl
2014 19–20 MPG 3.5L 6-cyl
2013 20 MPG 3.5L 6-cyl
2012 19–20 MPG 3.5L 6-cyl
2011 17 MPG 3.5L 6-cyl
2010 17–18 MPG 3.5L 6-cyl
2009 17–18 MPG 3.5L 6-cyl
2008 17 MPG 3.5L 6-cyl
2007 17 MPG 3.5L 6-cyl
2006 16 MPG 3.5L 6-cyl
2005 15 MPG 3.7L 6-cyl
2004 15 MPG 3.7L 6-cyl
2003 15 MPG 3.7L 6-cyl

2015 Mercedes-Benz Ml350: engines & MPG

The 2015 Ml350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 19 to 20 MPG.

VersionEngineTransmissionFuelCityHwyCombined
ML350 3.5L 6-cyl Automatic 7-spd Premium 18 23 20 MPG
ML350 4matic 3.5L 6-cyl Automatic 7-spd Premium 18 22 19 MPG

2014 Mercedes-Benz Ml350: engines & MPG

The 2014 Ml350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 19 to 20 MPG.

VersionEngineTransmissionFuelCityHwyCombined
ML350 3.5L 6-cyl Automatic 7-spd Premium 18 23 20 MPG
ML350 4matic 3.5L 6-cyl Automatic 7-spd Premium 18 22 19 MPG

2013 Mercedes-Benz Ml350: engines & MPG

The 2013 Ml350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy of 20 MPG.

VersionEngineTransmissionFuelCityHwyCombined
ML350 4matic 3.5L 6-cyl Automatic 7-spd Premium 18 23 20 MPG
ML350 3.5L 6-cyl Automatic 7-spd Premium 18 23 20 MPG

2012 Mercedes-Benz Ml350: engines & MPG

The 2012 Ml350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 19 to 20 MPG.

VersionEngineTransmissionFuelCityHwyCombined
ML350 4matic 3.5L 6-cyl Automatic 7-spd Premium 18 23 20 MPG
ML350 4matic 3.5L 6-cyl Automatic 7-spd Premium 17 22 19 MPG

2011 Mercedes-Benz Ml350: engines & MPG

The 2011 Ml350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy of 17 MPG.

VersionEngineTransmissionFuelCityHwyCombined
ML350 4matic 3.5L 6-cyl Automatic 7-spd Premium 15 20 17 MPG
ML350 3.5L 6-cyl Automatic 7-spd Premium 16 21 17 MPG

2010 Mercedes-Benz Ml350: engines & MPG

The 2010 Ml350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 17 to 18 MPG.

VersionEngineTransmissionFuelCityHwyCombined
ML350 3.5L 6-cyl Automatic 7-spd Premium 16 21 18 MPG
ML350 4matic 3.5L 6-cyl Automatic 7-spd Premium 15 20 17 MPG

2009 Mercedes-Benz Ml350: engines & MPG

The 2009 Ml350 was EPA-rated in 2 versions (3.5L 6-cyl), with combined economy from 17 to 18 MPG.

VersionEngineTransmissionFuelCityHwyCombined
ML350 3.5L 6-cyl Automatic 7-spd Premium 16 21 18 MPG
ML350 4matic 3.5L 6-cyl Automatic 7-spd Premium 15 20 17 MPG

2008 Mercedes-Benz Ml350: engines & MPG

The 2008 Ml350 was EPA-rated in 1 version (3.5L 6-cyl), with combined economy of 17 MPG.

VersionEngineTransmissionFuelCityHwyCombined
ML350 4matic 3.5L 6-cyl Automatic 7-spd Premium 15 20 17 MPG

2007 Mercedes-Benz Ml350: engines & MPG

The 2007 Ml350 was EPA-rated in 1 version (3.5L 6-cyl), with combined economy of 17 MPG.

VersionEngineTransmissionFuelCityHwyCombined
ML350 4matic 3.5L 6-cyl Automatic 7-spd Premium 15 20 17 MPG

2006 Mercedes-Benz Ml350: engines & MPG

The 2006 Ml350 was EPA-rated in 1 version (3.5L 6-cyl), with combined economy of 16 MPG.

VersionEngineTransmissionFuelCityHwyCombined
ML350 3.5L 6-cyl Automatic 7-spd Premium 14 19 16 MPG

2005 Mercedes-Benz Ml350: engines & MPG

The 2005 Ml350 was EPA-rated in 1 version (3.7L 6-cyl), with combined economy of 15 MPG.

VersionEngineTransmissionFuelCityHwyCombined
ML350 3.7L 6-cyl Automatic 5-spd Premium 14 17 15 MPG

2004 Mercedes-Benz Ml350: engines & MPG

The 2004 Ml350 was EPA-rated in 1 version (3.7L 6-cyl), with combined economy of 15 MPG.

VersionEngineTransmissionFuelCityHwyCombined
ML350 3.7L 6-cyl Automatic 5-spd Premium 14 17 15 MPG

2003 Mercedes-Benz Ml350: engines & MPG

The 2003 Ml350 was EPA-rated in 1 version (3.7L 6-cyl), with combined economy of 15 MPG.

VersionEngineTransmissionFuelCityHwyCombined
ML350 3.7L 6-cyl Automatic 5-spd Premium 14 17 15 MPG

Frequently asked questions

What MPG does a Mercedes-Benz Ml350 get?

Depending on year and engine, EPA combined ratings for the Ml350 range from 15 to 20 MPG. The most efficient rated version is the 2015 model year.

What engines does the 2015 Mercedes-Benz Ml350 have?

The 2015 Ml350 was EPA-rated with 3.5L 6-cyl engines — see the 2015 table above for each version's exact city/highway figures.

Does the Mercedes-Benz Ml350 require premium gas?

Yes — every EPA-rated gas Ml350 version specifies premium gasoline.

About this data: EPA ratings from the official U.S. DOE/EPA dataset (fueleconomy.gov), as of September 2026; refreshed monthly. Market prices and listing counts are live medians from VehiSales inventory, updated daily. How to cite: “VehiSales Research, Mercedes-Benz Ml350 EPA Fuel Economy by Model Year” with a link to https://vehisales.com/research/fuel-economy/mercedes-benz/ml350.

Fuel economy of other models

Mercedes-Benz GLC-Class MPG by year · Mercedes-Benz GLE-Class MPG by year · Mercedes-Benz C-Class MPG by year · Mercedes-Benz E-Class MPG by year

See also: Mercedes-Benz Ml350 hub — live listings, prices & reliability · Most fuel-efficient cars by segment · Model price trends. Media inquiries: [email protected].

© 2026 VehiSales · Data from live US vehicle listings · Methodology · Editorial policy · About · Press: cite as “VehiSales Used Car Price Index” with a link to this page.